Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57379 | 0.77 | TDP1 (0.46) | TDP1APLNRMEN1GAAKMT2A | |
| SCHEMBL4815929 | 0.77 | — | — | |
| SCHEMBL13515749 | 0.72 | NPSR1 (0.37) | MEN1KMT2A | |
| SCHEMBL16913 | 0.72 | TDP1 (0.48) | TDP1MEN1GAAKMT2A | |
| SCHEMBL10258326 | 0.71 | TDP1 (0.42) | TDP1APLNRMEN1GAAKMT2A | |
| SCHEMBL30993122 | 0.71 | CA1 (0.40) | TDP1APLNRMEN1GAAKMT2A | |
| SCHEMBL21018528 | 0.70 | TDP1 (0.41) | TDP1APLNRMEN1GAAKMT2A | |
| SCHEMBL12711702 | 0.69 | TDP1 (0.47) | TDP1MEN1GAAKMT2A | |
| SCHEMBL7879772 | 0.68 | CTSS (0.36) | TDP1MEN1GAAKMT2A | |
| SCHEMBL18254602 | 0.67 | TDP1 (0.38) | TDP1APLNRMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147093-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044728-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-08-03 | — | — | WO | disclosed |