Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.36 |
| ▸ | CTSK | P43235 | 10/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241159 | 0.72 | AAK1 (0.50) | AAK1 | |
| SCHEMBL30326251 | 0.72 | AAK1 (0.50) | AAK1 | |
| SCHEMBL55502 | 0.71 | TDP1 (0.46) | CTSKKMT2AMEN1GAAAAK1 | |
| SCHEMBL22644353 | 0.70 | APLNR (0.41) | CTSKKMT2AMEN1GAAAAK1 | |
| SCHEMBL16913 | 0.69 | TDP1 (0.48) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL19502944 | 0.68 | KMT2A (0.59) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL1484195 | 0.68 | KMT2A (0.59) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL7879768 | 0.68 | TDP1 (0.34) | KMT2AMEN1GAATDP1 | |
| SCHEMBL18138208 | 0.67 | TDP1 (0.40) | KMT2AMEN1GAAAAK1TDP1 | |
| SCHEMBL12712549 | 0.66 | CTSS (0.74) | CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147093-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044728-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-08-03 | — | — | WO | disclosed |