SCHEMBL7880264

SCHEMBL7880264

O=C(c1ccc(Cl)cc1)N1CCc2sccc2C1c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LHCGR P22888 11/20 0.60
NPSR1 Q6W5P4 2/20 0.58
MAPK1 P28482 1/20 0.58
POLB P06746 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MGLL Q99685 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7889847 0.91 NPSR1 (0.55) LHCGRNPSR1MAPK1POLBL3MBTL1
SCHEMBL7887769 0.90 POLB (0.52) LHCGRNPSR1POLBL3MBTL1
SCHEMBL7889959 0.90 LHCGR (0.55) LHCGRNPSR1POLBL3MBTL1
SCHEMBL7887385 0.90 POLB (0.63) LHCGRNPSR1POLBL3MBTL1
SCHEMBL7887366 0.89 LHCGR (0.53) LHCGRNPSR1MAPK1POLBL3MBTL1
SCHEMBL7887722 0.88 MAPK1 (0.72) LHCGRNPSR1MAPK1
SCHEMBL7880247 0.88 NPSR1 (0.49) LHCGRNPSR1MAPK1POLBL3MBTL1
SCHEMBL7880322 0.88 HHAT (0.52) LHCGRNPSR1POLBL3MBTL1
SCHEMBL7887505 0.88 POLB (0.53) LHCGRNPSR1POLBL3MBTL1
SCHEMBL7880476 0.88 NPSR1 (0.50) LHCGRNPSR1MAPK1POLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6177443-B1 ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 2001-01-23 US disclosed
EP-0973778-A1 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2000-01-26 EP disclosed
WO-1998040385-A1 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-09-17 WO disclosed