Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680236 | 0.87 | GPR119 (0.48) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL2679959 | 0.83 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL6890507 | 0.79 | CDK2 (0.48) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL10277723 | 0.79 | CDK2 (0.48) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL17787557 | 0.79 | CHEK1 (0.43) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL11931257 | 0.78 | CHEK1 (0.50) | CHEK1CCNA2CDK2CCNA1GPR119 | |
| SCHEMBL593655 | 0.78 | CDK2 (0.54) | CHEK1CCNA2CDK2CCNA1PDE10A | |
| SCHEMBL7846641 | 0.77 | CHEK1 (0.68) | CHEK1CCNA2CDK2CCNA1PDE10A | |
| SCHEMBL2680289 | 0.76 | GPR119 (0.50) | GPR119KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL2679455 | 0.74 | GPR119 (0.48) | GPR119KDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |