Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872384 | 0.84 | KARS1 (0.43) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL7872421 | 0.84 | LMNA (0.47) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL7880185 | 0.75 | KARS1 (0.63) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL21281905 | 0.74 | MAPK10 (0.50) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL7872531 | 0.74 | KARS1 (0.55) | SMN1; SMN2NPC1RAB9AKMT2AKARS1 | |
| SCHEMBL2912518 | 0.72 | KDR (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18772775 | 0.72 | TNNI3K (0.59) | SMN1; SMN2NPC1RAB9ATP53KMT2A | |
| SCHEMBL7878698 | 0.71 | KARS1 (0.49) | NPC1ALDH1A1KMT2AKARS1KDM4E | |
| SCHEMBL7880192 | 0.70 | KARS1 (0.48) | NPC1KMT2AKARS1NOS2 | |
| SCHEMBL27524202 | 0.70 | KARS1 (0.48) | NPC1ALDH1A1KMT2AKARS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1244542-C | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2006-03-08 | — | — | CN | claimed |
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | claimed |
| CN-1240419-A | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2000-01-05 | — | — | CN | claimed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | claimed |
| CN-1244542-C | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2006-03-08 | — | — | CN | disclosed |
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| CN-1240419-A | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2000-01-05 | — | — | CN | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |