Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | HTR3A | P46098 | 1/20 | 0.72 |
| ▸ | CASP6 | P55212 | 1/20 | 0.71 |
| ▸ | CD44 | P16070 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lurosetron SCHEMBL30949356 | 1.00 | KCNH2 (0.72) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL7291773 | 0.99 | CASP6 (0.72) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL7336906 | 0.99 | KCNH2 (0.71) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL635328 | 0.95 | KCNH2 (0.66) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL7336554 | 0.95 | KCNH2 (0.65) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL7282816 | 0.93 | KCNH2 (0.63) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL9486016 | 0.93 | KCNH2 (0.63) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| Lurosetron SCHEMBL7284073 | 0.92 | KCNH2 (0.65) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| SCHEMBL7285588 | 0.90 | KCNH2 (0.74) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A | |
| SCHEMBL7293493 | 0.88 | KCNH2 (0.72) | KCNH2CYP1A2CYP3A4ADRA2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11547700-B2 | Compositions and methods for treating synucleinopathies | CHASE THERAPEUTICS CORPORATION (US) | 2023-01-10 | — | — | US | claimed |
| WO-2016118540-A1 | TREATING AND/OR PREVENTING EMESIS AND/OR NAUSEA INCLUDING ACUTE AND/OR DELAYED NAUSEA AND/OR EMESIS | Xoc Pharmaceuticals, Inc. (US) | 2016-07-28 | — | — | WO | claimed |
| US-20160206610-A1 | METHODS FOR TREATING AND/OR PREVENTING EMESIS AND/OR NAUSEA INCLUDING ACUTE AND/OR DELAYED NAUSEA AND/OR ACUTE EMESIS AND/OR DELAYED EMESIS | Xoc Pharmaceuticals, Inc. | 2016-07-21 | — | — | US | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| CN-103402513-A | Composition for preventing nausea or vomiting | SAMYANG BIOPHARMACEUTICALS | 2013-11-20 | — | — | CN | claimed |
| EP-2658539-A2 | COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING | Samyang Biopharmaceuticals Corporation (KR) | 2013-11-06 | — | — | EP | claimed |
| US-20130267487-A1 | COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING | SAMYANG BIOPHARMACEUTICALS CORPORATION (KR) | 2013-10-10 | — | — | US | claimed |
| WO-2012091357-A2 | COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING | SAMYANG BIOPHARMACEUTICALS CORPORATION (KR) | 2012-07-05 | — | — | WO | claimed |
| CN-1925846-B | Use of a 5-HT3 receptor antagonist for the manufacture of a medicament for the treatment of non-digestive tract derived abdominal disorders associated with pain | SOLVAY PHARM BV | 2011-11-16 | — | — | CN | claimed |
| US-20100226943-A1 | SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL | UNIVERSITY OF FLORIDA (US) | 2010-09-09 | — | — | US | claimed |
| US-6235745-B1 | ADMINISTERING WITH LAXATIVE | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-05-22 | — | — | US | claimed |
| EP-0975327-A1 | USE OF 5HT3 ANTAGONISTS FOR PROMOTING INTESTINAL LAVAGE | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-02 | — | — | EP | claimed |
| WO-1998047481-A1 | USE OF 5HT3 ANTAGONISTS FOR PROMOTING INTESTINAL LAVAGE | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-29 | — | — | WO | claimed |
| EP-0546593-B1 | Multi-layered compositions containing histamine or serotonin antagonists | GLAXO GROUP LTD (GB) | 1997-09-03 | — | — | EP | claimed |
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | claimed |
| EP-0542364-B1 | Controlled release device | GLAXO CANADA (CA) | 1996-01-24 | — | — | EP | claimed |
| US-5425950-A | Antiserotonine agent | GLAXO GROUP LIMITED (GB) | 1995-06-20 | — | — | US | claimed |
| EP-0546593-A1 | Multi-layered compositions containing histamine or serotonin antagonists | GLAXO GROUP LIMITED (GB) | 1993-06-16 | — | — | EP | claimed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | claimed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | claimed |