Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 14/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503869 | 0.75 | HSD17B10 (0.40) | — | |
| SCHEMBL788917 | 0.75 | PKN1 (0.33) | — | |
| SCHEMBL31268919 | 0.75 | HSD17B10 (0.40) | — | |
| SCHEMBL4521136 | 0.73 | — | — | |
| SCHEMBL31339136 | 0.71 | CSNK2A1 (0.39) | — | |
| SCHEMBL17065965 | 0.70 | LOXL2 (0.43) | LOXL2ULK1L3MBTL1SCN9ASCN10A | |
| SCHEMBL4650850 | 0.70 | NAMPT (0.43) | LOXL2ULK1L3MBTL1KCNH2 | |
| SCHEMBL11145156 | 0.68 | EGLN1 (0.38) | LOXL2ULK1 | |
| SCHEMBL13134193 | 0.67 | EGFR (0.30) | — | |
| SCHEMBL277594 | 0.67 | EGFR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |