SCHEMBL31339136

SCHEMBL31339136

COC(=O)c1nc2cncnc2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 1/20 0.39
TSHR P16473 1/20 0.36
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 2/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34
FGFR1 P11362 1/20 0.34
FGFR2 P21802 1/20 0.34
ATM Q13315 1/20 0.33
MAPK1 P28482 1/20 0.33
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33
F2 P00734 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268919 0.81 HSD17B10 (0.40) CSNK2A1ALDH1A1KDM4ELMNAHSD17B10
SCHEMBL788917 0.81 PKN1 (0.33) TSHRMAPK1
SCHEMBL12503869 0.81 HSD17B10 (0.40) CSNK2A1ALDH1A1KDM4ELMNAHSD17B10
SCHEMBL4521136 0.80
SCHEMBL13134193 0.77 EGFR (0.30)
SCHEMBL3368051 0.74 MAP2K1 (0.48) ALDH1A1KDM4EGAANPSR1LMNA
SCHEMBL159763 0.73 ALDH1A1 (0.44) CSNK2A1ALDH1A1KDM4EGLAGAA
SCHEMBL6798635 0.73 EGFR (0.39) TSHRALDH1A1MAPK1HSD17B10
SCHEMBL18969568 0.71 ABL1 (0.47) MAPK1
SCHEMBL788381 0.71 LOXL2 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119031913-A Purine and methods of use thereof 奇尼塔公司 2024-11-26 CN disclosed