Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885157 | 0.89 | KMT2A (0.54) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL251644 | 0.79 | ALDH1A1 (0.43) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL1283693 | 0.78 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL1964058 | 0.77 | ALDH1A1 (0.42) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL633344 | 0.77 | HTT (0.54) | KMT2AALDH1A1MEN1LMNAHPGD | |
| SCHEMBL15839989 | 0.77 | MEN1 (0.57) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL14071502 | 0.75 | KMT2A (0.50) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL10961976 | 0.74 | CYP2A6 (0.50) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL19411968 | 0.74 | ALDH1A1 (0.43) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL1187729 | 0.74 | GAA (0.50) | KMT2AALDH1A1MEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147093-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044728-A1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-08-03 | — | — | WO | disclosed |