Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9598331 | 0.77 | ADORA1 (0.64) | MKNK1P2RX3KDM4EPRKCIADORA1 | |
| SCHEMBL1017080 | 0.76 | KDM4E (0.76) | MKNK1P2RX3KDM4ERXFP1 | |
| SCHEMBL4059322 | 0.73 | P2RX3 (0.52) | MKNK1P2RX3PRKCIADORA1 | |
| SCHEMBL7878742 | 0.72 | CYP1A2 (0.58) | KDM4ERXFP1 | |
| SCHEMBL12284281 | 0.71 | ADORA1 (0.55) | MKNK1P2RX3KDM4ERXFP1PRKCI | |
| Hydrochloric Acid SCHEMBL7887965 | 0.71 | CYP1A2 (0.57) | KDM4ERXFP1 | |
| SCHEMBL24996003 | 0.71 | MKNK1 (0.66) | MKNK1P2RX3ADORA1 | |
| SCHEMBL30879369 | 0.71 | MKNK1 (0.66) | MKNK1P2RX3ADORA1 | |
| SCHEMBL18358077 | 0.71 | P2RX3 (0.66) | MKNK1P2RX3RXFP1 | |
| SCHEMBL8204125 | 0.71 | KDM4E (0.48) | MKNK1P2RX3KDM4ERXFP1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107304-A | ANEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-22 | — | — | US | claimed |
| EP-0869790-A4 | THIENO(2,3-b)PYRAZOLO(3,4-d)PYRIDIN-3-ONES TO ENHANCE ERYTHROPOIESIS | SMITHKLINE BEECHAM CORP (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6107304-A | ANEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0869790-A1 | THIENO(2,3-b)PYRAZOLO(3,4-d)PYRIDIN-3-ONES TO ENHANCE ERYTHROPOIESIS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024120-A1 | THIENO(2,3-b)PYRAZOLO(3,4-d)PYRIDIN-3-ONES TO ENHANCE ERYTHROPOIESIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |