Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890459 | 0.77 | ELANE (0.49) | KDM4EMAPTL3MBTL1KMT2AHSP90AA1 | |
| SCHEMBL7886473 | 0.77 | FEN1 (0.37) | KDM4EMAPTL3MBTL1KMT2AHSP90AA1 | |
| SCHEMBL13658230 | 0.77 | KDM5A (0.41) | KDM4EMAPTAXLL3MBTL1HSP90AA1 | |
| SCHEMBL30509506 | 0.73 | L3MBTL1 (0.45) | L3MBTL1FEN1ELANE | |
| SCHEMBL20689382 | 0.73 | RET (0.38) | L3MBTL1HSP90AA1FEN1NPC1 | |
| SCHEMBL29248280 | 0.72 | ELANE (0.46) | KDM4EL3MBTL1KMT2AHSP90AA1MEN1 | |
| SCHEMBL30204143 | 0.69 | L3MBTL1 (0.36) | KDM4EAXLL3MBTL1ALDH1A1LDHA | |
| SCHEMBL9940661 | 0.69 | L3MBTL1 (0.36) | KDM4EAXLL3MBTL1ALDH1A1LDHA | |
| SCHEMBL12146948 | 0.69 | ELANE (0.43) | KDM4EMAPTAXLL3MBTL1KMT2A | |
| SCHEMBL20689380 | 0.66 | RET (0.44) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111527-A1 | PYRAZOLO [ 3, 4 -B] PYRIDINES AS KINASE INHIBITORS AND THEIR MEDICAL USE | PLEXXIKON, INC. (US) | 2010-09-30 | — | — | WO | disclosed |