Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747623 | 0.78 | GSK3B (0.54) | ELANEHSP90AA1HSP90AB1IDO1PSMB5 | |
| SCHEMBL29224069 | 0.78 | ELANE (0.50) | ELANEHSP90AA1HSP90AB1IDO1PSMB5 | |
| SCHEMBL1585571 | 0.77 | ELANE (0.49) | ELANEHSP90AA1HSP90AB1IDO1PSMB5 | |
| SCHEMBL7886473 | 0.77 | FEN1 (0.37) | HSP90AA1ALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL7886641 | 0.77 | KDM4E (0.35) | ELANEHSP90AA1HSP90AB1ALDH1A1NR4A2 | |
| SCHEMBL1747314 | 0.73 | KDM4E (0.47) | ELANEALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL26597006 | 0.73 | RET (0.46) | ELANEALDH1A1HPGDLMNAHTT | |
| SCHEMBL26675399 | 0.72 | ELANE (0.55) | ELANEGSK3B | |
| SCHEMBL30675625 | 0.72 | ELANE (0.55) | ELANEGSK3B | |
| SCHEMBL12146969 | 0.69 | HSP90AA1 (0.42) | ELANEHSP90AA1HSP90AB1IDO1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111527-A1 | PYRAZOLO [ 3, 4 -B] PYRIDINES AS KINASE INHIBITORS AND THEIR MEDICAL USE | PLEXXIKON, INC. (US) | 2010-09-30 | — | — | WO | disclosed |