Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887431 | 0.88 | PIK3CA (0.43) | PIK3CAPIK3CDMTOR | |
| SCHEMBL7882360 | 0.88 | PIK3CA (0.41) | PIK3CAPIK3CDMTOR | |
| SCHEMBL7884020 | 0.86 | PLAT (0.49) | PIK3CAMTOR | |
| SCHEMBL10235107 | 0.84 | MTOR (0.42) | PIK3CAMTOR | |
| SCHEMBL15006923 | 0.84 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL7875015 | 0.84 | MET (0.33) | PIK3CAMTOR | |
| SCHEMBL10234699 | 0.84 | MTOR (0.42) | MTOR | |
| SCHEMBL15007228 | 0.84 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL10234684 | 0.83 | MTOR (0.40) | MTOR | |
| SCHEMBL10234695 | 0.83 | NPC1 (0.42) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |