Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7893585 | 0.91 | NAMPT (0.51) | RBP4NAMPTMAPTSETD7KDM4E | |
| SCHEMBL3714521 | 0.83 | KDM4E (0.55) | RBP4MAPTNPC1TP53RAB9A | |
| SCHEMBL3599162 | 0.82 | MAPT (0.68) | RBP4NAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL31587841 | 0.81 | SETD7 (0.65) | SETD7PDK1PDK2PDK3PDK4 | |
| SCHEMBL14122007 | 0.80 | SETD7 (0.52) | SETD7KDM4EPDK1PDK2PDK3 | |
| SCHEMBL19284201 | 0.79 | MEN1 (0.50) | NAMPTMAPTSETD7NPC1TP53 | |
| SCHEMBL16707786 | 0.79 | MAPT (0.73) | RBP4NAMPTMAPTKDM4EALDH1A1 | |
| SCHEMBL3709509 | 0.78 | KDM4E (0.51) | RBP4MAPTNPC1TP53RAB9A | |
| SCHEMBL19284243 | 0.78 | ALDH1A1 (0.58) | NAMPTMAPTSETD7NPC1RAB9A | |
| SCHEMBL3605934 | 0.78 | NAMPT (0.48) | RBP4NAMPTMAPTKDM4ECCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |