SCHEMBL788818

SCHEMBL788818

N[C@]1(O)CCc2ccccc21

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.50
MAOB P27338 1/20 0.50
HDAC9 Q9UKV0 1/20 0.41
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
HTR2A P28223 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HCAR2 Q8TDS4 1/20 0.39
LMNA P02545 1/20 0.39
SLC18A3 Q16572 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2147836 1.00 KDM1A (0.50) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL29529186 1.00 KDM1A (0.50) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL30316454 1.00 KDM1A (0.50) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL594461 1.00 KDM1A (0.50) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL30664080 1.00 KDM1A (0.50) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL7395445 0.98 KDM1A (0.48) KDM1AMAOBHDAC9TSHRTDP1
Acetone SCHEMBL3363093 0.91 KDM1A (0.44) KDM1AMAOBHDAC9TSHRTDP1
SCHEMBL6440070 0.88 KDM1A (0.56) KDM1AMAOBTSHRHTR2AMAPK1
Trifluoroacetic Acid SCHEMBL4280581 0.85 HDAC9 (0.42) KDM1AMAOBHDAC9TSHRTDP1
P-Toluenesulfonamide SCHEMBL5528880 0.79 CA2 (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7560482-B2 Inhibitors of plasmepsins THE JOHNS HOPKINS UNIVERSITY (US) 2009-07-14 US claimed
US-20050037953-A1 Inhibitors of plasmepsins NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-02-17 US claimed
CN-1083425-C Regiospecific process to make cis-1-amino-2-alkanol from epoxide MERCK & CO INC (US) 2002-04-24 CN claimed
CN-1077881-C Regiospecific processes to make cis-1-amino-2-alkanol from diol or halohydrin MERCK & CO INC (US) 2002-01-16 CN claimed
US-6171832-B1 FERMENTING STARTING MATERIAL IN CULTURE, RECOVERING PRODUCT; BY PRODUCT INHIBITION; CHEMICAL INTERMEDIATE FOR SYNTHESIS OF INDINAVIR, A POTENT HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITOR MERCK & CO., INC. 2001-01-09 US claimed
US-5871981-A COMPOUNDS FOR TREATMENT OF AIDS MERCK & CO., INC. (US) 1999-02-16 US claimed
US-5858737-A INCUBATING MIXTURE OF INDENE AND PSEUDOMONAS PUTIDA TO GIVE DESIRED ISOMER OF INDANDIOL MERCK & CO., INC. (US) 1999-01-12 US claimed
CN-1147243-A Regiospecific process for the preparation of cis-1-amino-2-alkanols from epoxides MERCK & CO INC (US) 1997-04-09 CN claimed
CN-1147244-A Regiospecific processes to make cis-1-amino-2-alkanol from diol or halohydrin MERCK & CO INC (US) 1997-04-09 CN claimed
US-5489710-A AMINATION BY MIXING WITH NITRILE SOLVENT, ACIDIFICATION AND HYDROLYZING WITH WATER MERCK & CO., INC. (US) 1996-02-06 US claimed
US-5449830-A Enzyme inhibitors for protease encoded for HIV MARCK & CO., INC. (US) 1995-09-12 US claimed
US-5420353-A Protease inhibitors, AIDS MERCK & CO., INC. (US) 1995-05-30 US claimed
US-8357524-B2 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity DANISCO US INC. (US) 2013-01-22 US disclosed
US-20120295329-A1 CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2012-11-22 US disclosed
US-20120156721-A1 CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2012-06-21 US disclosed
US-8148128-B2 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2012-04-03 US disclosed
US-5420353-A Protease inhibitors, AIDS MERCK & CO., INC. (US) 1995-05-30 US disclosed
EP-0601486-A1 Cis-epoxide derivatives useful as irreversible HIV protease inhibitors and process and intermediates for their preparation LUCKY LTD. (KR) 1994-06-15 EP disclosed
EP-0552309-A1 NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS MERCK & CO. INC. (US) 1993-07-28 EP disclosed
WO-1992006992-A2 NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS MERCK & CO., INC. (US) 1992-04-30 WO disclosed