Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566656 | 0.94 | KDM1A (0.53) | KDM1AEGFRIRAK1IRAK4BRAF | |
| Hydrochloric Acid SCHEMBL5566338 | 0.93 | KDM1A (0.52) | KDM1AEGFRIRAK1IRAK4BRAF | |
| SCHEMBL5565868 | 0.91 | KDM1A (0.56) | KDM1AEGFRIRAK1IRAK4BRAF | |
| Hydrochloric Acid SCHEMBL5566986 | 0.90 | KDM1A (0.55) | KDM1AEGFRIRAK1IRAK4BRAF | |
| SCHEMBL5565927 | 0.82 | KDM1A (0.54) | KDM1AEGFRBRAFRAF1PDGFRB | |
| SCHEMBL5566781 | 0.82 | EGFR (0.50) | EGFRIRAK1IRAK4BRAFPDGFRB | |
| SCHEMBL5560937 | 0.81 | KDM1A (0.47) | KDM1AEGFRBRAFRAF1PDGFRB | |
| Hydrochloric Acid SCHEMBL5566335 | 0.80 | KDM1A (0.46) | KDM1AEGFRBRAFRAF1PDGFRB | |
| SCHEMBL7885709 | 0.78 | KDR (0.53) | EGFRPDGFRBKITPDGFRAKDR | |
| SCHEMBL7884841 | 0.77 | KDM1A (0.41) | KDM1AEGFRIRAK1IRAK4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | claimed |