Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | HNF4A | P41235 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761259 | 0.88 | RXRA (0.50) | BACE1RXRAHNF4ATTRDPP4 | |
| SCHEMBL7762902 | 0.88 | RXRA (0.50) | BACE1RXRAHNF4ATTRDPP4 | |
| SCHEMBL7760216 | 0.88 | BACE1 (0.45) | BACE1RXRATTRDPP4CA12 | |
| SCHEMBL7889498 | 0.87 | RXRA (0.52) | RXRAHNF4ACYP3A4KDM4ERARA | |
| SCHEMBL7756631 | 0.87 | RXRA (0.52) | RXRAHNF4ACYP3A4KDM4ERARA | |
| SCHEMBL7761308 | 0.80 | RXRA (0.49) | BACE1RXRATTRDPP4CA12 | |
| SCHEMBL7761301 | 0.80 | RXRA (0.49) | BACE1RXRATTRDPP4CA12 | |
| SCHEMBL7761315 | 0.79 | RARA (0.39) | BACE1RXRATTRDPP4CA12 | |
| SCHEMBL6874284 | 0.78 | RXRA (0.50) | BACE1RXRATTRDPP4CA12 | |
| SCHEMBL6880803 | 0.75 | RARA (0.50) | BACE1RXRATTRDPP4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | claimed |
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |