Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.81 |
| ▸ | NPC1 | O15118 | 11/20 | 0.68 |
| ▸ | RAB9A | P51151 | 10/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477522 | 0.95 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL788729 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL6677954 | 0.86 | CYP1A2 (0.70) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL4524922 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL1184757 | 0.82 | CYP1A2 (0.60) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL29242622 | 0.82 | CYP1A2 (0.70) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL14451161 | 0.81 | MAPT (0.72) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL8188470 | 0.81 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL11285291 | 0.79 | RAB9A (0.73) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL357806 | 0.79 | CYP1A2 (0.61) | SMN1; SMN2NPC1RAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |