Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of E968. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E968 SCHEMBL23071561 | 1.00 | LMNA (0.53) | LMNAL3MBTL1TSHRTDP1ALDH1A1 | |
| E968 SCHEMBL18039459 | 0.92 | LMNA (0.53) | LMNAL3MBTL1TSHRTDP1ALDH1A1 | |
| E968 SCHEMBL22638782 | 0.88 | LMNA (0.50) | LMNAL3MBTL1TSHRTDP1ALDH1A1 | |
| E968 SCHEMBL22638789 | 0.88 | LMNA (0.50) | LMNAL3MBTL1TSHRTDP1ALDH1A1 | |
| E968 SCHEMBL121807 | 0.87 | — | — | |
| E968 SCHEMBL17766 | 0.87 | — | — | |
| E968 SCHEMBL17062 | 0.87 | — | — | |
| E968 SCHEMBL10427336 | 0.87 | — | — | |
| E968 SCHEMBL2723809 | 0.87 | LMNA (0.67) | LMNAL3MBTL1TSHRTDP1ALDH1A1 | |
| E968 SCHEMBL6729753 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024150897-A1 | FOAMING AGENT COMPOSITION FOR POLYURETHANE AND METHOD OF PREPARING POLYURETHANE FOAM USING SAME | 주식회사 세호 | 2024-07-18 | — | — | WO | disclosed |
| EP-4400537-A1 | FOAMING AGENT COMPOSITION FOR POLYURETHANE AND METHOD OF PREPARING POLYURETHANE FOAM USING SAME | Seho Inc. (KR) | 2024-07-17 | — | — | EP | disclosed |
| CN-118119278-A | Method for producing fermented dairy products for environmental storage | 科·汉森有限公司 | 2024-05-31 | — | — | CN | disclosed |
| US-20240033255-A1 | ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | ZHUHAI UNITED LABORATORIES CO., LTD. (CN) | 2024-02-01 | — | — | US | disclosed |
| EP-4285899-A1 | ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Zhuhai United Laboratories Co., Ltd. (CN) | 2023-12-06 | — | — | EP | disclosed |
| CN-110769838-B | microbial composition | 普罗比公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116193987-A | Methods and compositions | 亚伦·廷达尔 | 2023-05-30 | — | — | CN | disclosed |
| US-11661477-B2 | Star-shaped poly(propylene fumarate) copolymers for 3D printing applications | THE UNIVERSITY OF AKRON (US) | 2023-05-30 | — | — | US | disclosed |
| US-11541082-B2 | Microbial compositions | PROBI AB (SE) | 2023-01-03 | — | — | US | disclosed |
| CN-113038974-B | Star-shaped poly (propylene fumarate) copolymers for 3D printing applications | 阿克伦大学 | 2022-11-08 | — | — | CN | disclosed |
| US-5306516-A | Reduced fat and calorie polyol fatty acid esters | THE PROCTER & GAMBLE COMPANY (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0531306-A4 | SHORTENING COMPOSITIONS CONTAINING POLYOL FATTY ACID POLYESTERS | — | 1993-04-28 | — | — | EP | disclosed |
| EP-0526526-A4 | NOVEL SOLID, NONDIGESTIBLE, FAT-LIKE COMPOUNDS AND FOOD COMPOSITIONS CONTAINING SAME | — | 1993-04-14 | — | — | EP | disclosed |
| EP-0526499-A4 | REDUCED CALORIE POURABLE SHORTENINGS, COOKING OILS, SALAD OILS OR LIKE COMPOSITIONS | — | 1993-04-14 | — | — | EP | disclosed |
| EP-0531306-A1 | SHORTENING COMPOSITIONS CONTAINING POLYOL FATTY ACID POLYESTERS. | PROCTER & GAMBLE (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0526526-A1 | NOVEL SOLID, NONDIGESTIBLE, FAT-LIKE COMPOUNDS AND FOOD COMPOSITIONS CONTAINING SAME. | PROCTER & GAMBLE (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0526499-A1 | REDUCED CALORIE POURABLE SHORTENINGS, COOKING OILS, SALAD OILS OR LIKE COMPOSITIONS. | PROCTER & GAMBLE (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991015963-A1 | SHORTENING COMPOSITIONS CONTAINING POLYOL FATTY ACID POLYESTERS | THE PROCTER & GAMBLE COMPANY (US) | 1991-10-31 | — | — | WO | disclosed |
| WO-1991015960-A1 | NOVEL SOLID, NONDIGESTIBLE, FAT-LIKE COMPOUNDS AND FOOD COMPOSITIONS CONTAINING SAME | THE PROCTER & GAMBLE COMPANY (US) | 1991-10-31 | — | — | WO | disclosed |
| WO-1991015961-A1 | REDUCED CALORIE POURABLE SHORTENINGS, COOKING OILS, SALAD OILS OR LIKE COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1991-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240033255-A1 | ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | JAK1, JAK2, JAK3 | LMNA 4636/4885L3MBTL1 4291/4885TSHR 3736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.