Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053464 | 0.82 | MTNR1A (0.55) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL4053149 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL13743682 | 0.79 | MTNR1A (0.43) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL4048331 | 0.77 | HTR6 (0.52) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL4052414 | 0.76 | MTNR1A (0.43) | MTNR1AMTNR1BALDH1A1KDM4EHTT | |
| SCHEMBL6642682 | 0.76 | HTR6 (0.57) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL6642384 | 0.75 | HTR6 (0.56) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL4049847 | 0.74 | HTR6 (0.40) | MTNR1AMTNR1BPTGER4HTR6ALDH1A1 | |
| SCHEMBL7888632 | 0.71 | HTR2A (0.53) | MTNR1AMTNR1BALDH1A1HTR2AHTR2C | |
| SCHEMBL4056262 | 0.69 | KDM4E (0.49) | MTNR1AMTNR1BPTGER4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192147-A1 | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192147-A1 | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PIK3C2A | MTNR1A 2107/4885MTNR1B 2048/4885PTGER4 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.