Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506513 | 0.76 | DGAT1 (0.54) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL789058 | 0.75 | TMEM97 (0.47) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL1648482 | 0.74 | DGAT1 (0.59) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL13485811 | 0.73 | DGAT1 (0.63) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL27007857 | 0.73 | DGAT1 (0.63) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL9824866 | 0.73 | POLB (0.60) | LMNAKMT2ACYP3A4CYP2C9POLB | |
| SCHEMBL10720001 | 0.72 | POLB (0.63) | CYP3A4CYP2C9POLBABCB1 | |
| SCHEMBL6415816 | 0.71 | NPC1 (0.49) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL2925042 | 0.71 | TMEM97 (0.52) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL22530888 | 0.71 | DGAT1 (0.56) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616071-A2 | FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037299-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |