Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343083 | 0.75 | ALDH1A1 (0.51) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL789059 | 0.75 | TMEM97 (0.47) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL4031225 | 0.73 | RAB9A (0.48) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3345916 | 0.73 | DGAT1 (0.54) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL29403395 | 0.72 | KMT2A (0.44) | ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL2924440 | 0.71 | TMEM97 (0.49) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL2927270 | 0.71 | TMEM97 (0.49) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL793201 | 0.71 | DGAT1 (0.65) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL1648482 | 0.71 | DGAT1 (0.59) | TMEM97SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL27007857 | 0.70 | DGAT1 (0.63) | TMEM97SIGMAR1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616071-A2 | FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037299-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |