Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892110 | 1.00 | LMNA (0.43) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL7880901 | 1.00 | LMNA (0.43) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL7888501 | 1.00 | LMNA (0.43) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL11923661 | 1.00 | LMNA (0.43) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL7892540 | 1.00 | LMNA (0.43) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL17202943 | 0.86 | KMT2A (0.50) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL1068738 | 0.86 | KMT2A (0.50) | LMNAPOLBALDH1A1HPGDHTT | |
| SCHEMBL17202944 | 0.86 | KMT2A (0.50) | LMNAPOLBALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL1068734 | 0.84 | KMT2A (0.49) | LMNAPOLBALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL1068739 | 0.84 | KMT2A (0.49) | LMNAPOLBALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | LU, Jiasheng (CN) | 2016-08-04 | — | — | US | disclosed |
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | LU, Jiasheng (CN) | 2016-08-04 | — | — | US | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| WO-2010127439-A1 | AMMO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | LMNA 4214/4885POLB 4205/4885ALDH1A1 2327/4885 |
| US-20160220519-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | LMNA 4230/4885POLB 4172/4885ALDH1A1 2354/4885 |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | LMNA 4214/4885POLB 4205/4885ALDH1A1 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.