SCHEMBL7894010

SCHEMBL7894010

Cc1cccc(C)c1CNc1c(NC(C)(C)C)c(=O)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.38
HDAC3 O15379 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
CXCR2 P25025 2/20 0.38
CYP3A4 P08684 10/20 0.36
CD38 P28907 1/20 0.36
KCNH2 Q12809 1/20 0.36
CYP2C9 P11712 8/20 0.35
CYP2C19 P33261 7/20 0.35
CYP1A2 P05177 6/20 0.35
CYP2D6 P10635 4/20 0.35
CHEK2 O96017 3/20 0.33
GSK3A P49840 3/20 0.33
GSK3B P49841 3/20 0.33
RPS6KA3 P51812 3/20 0.33
ROCK1 Q13464 3/20 0.33
PRKACA P17612 2/20 0.33
RPS6KB1 P23443 2/20 0.33
NEK4 P51957 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7895056 0.90 CYP3A4 (0.41) HDAC1HDAC3HDAC2HDAC6CXCR2
SCHEMBL7886455 0.90 CYP3A4 (0.45) HDAC1HDAC3HDAC2HDAC6CXCR2
SCHEMBL7895653 0.86 PLK1 (0.37) HDAC1HDAC3HDAC2HDAC6CYP3A4
SCHEMBL7894120 0.84 CHEK2 (0.33) CXCR2CHEK2GSK3AGSK3BRPS6KA3
SCHEMBL7894237 0.84 HPGD (0.39) HDAC1HDAC3HDAC2HDAC6CXCR2
SCHEMBL7894202 0.83 KDM4C (0.40) HDAC1CXCR2CD38CHEK2GSK3A
SCHEMBL7894239 0.83 CHEK1 (0.39) HDAC1CXCR2CYP3A4CD38KCNH2
SCHEMBL7895628 0.81 ROCK2 (0.32) CHEK2GSK3AGSK3BRPS6KA3ROCK1
SCHEMBL7886982 0.79 PLK1 (0.51) HDAC1HDAC3HDAC2HDAC6CHEK2
SCHEMBL7895105 0.78 CYP3A4 (0.42) CYP3A4CD38P2RX7MAPK1PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP claimed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP claimed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US claimed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO claimed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed