SCHEMBL7895056

SCHEMBL7895056

Cc1cccc(Cl)c1CNc1c(NC(C)(C)C)c(=O)c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.41
CD38 P28907 2/20 0.41
HDAC8 Q9BY41 1/20 0.40
P2RX7 Q99572 7/20 0.38
EIF2AK1 Q9BQI3 2/20 0.37
ABL1 P00519 1/20 0.37
SRC P12931 1/20 0.37
SCN1A P35498 1/20 0.36
SCN5A Q14524 1/20 0.36
SCN8A Q9UQD0 1/20 0.36
HDAC3 O15379 2/20 0.35
HDAC1 Q13547 2/20 0.35
HDAC2 Q92769 2/20 0.35
HDAC6 Q9UBN7 2/20 0.35
HPGD P15428 1/20 0.35
PDK1 Q15118 1/20 0.35
PDK2 Q15119 1/20 0.35
PDK3 Q15120 1/20 0.35
PDK4 Q16654 1/20 0.35
CXCR2 P25025 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7894237 0.93 HPGD (0.39) CYP3A4CD38HDAC8EIF2AK1HDAC3
SCHEMBL7894010 0.90 HDAC1 (0.38) CYP3A4CD38P2RX7HDAC3HDAC1
SCHEMBL7895105 0.88 CYP3A4 (0.42) CYP3A4CD38HDAC8P2RX7EIF2AK1
SCHEMBL7886455 0.83 CYP3A4 (0.45) CYP3A4SCN5AHDAC3HDAC1HDAC2
SCHEMBL7894968 0.82 PLK1 (0.46) CYP3A4CD38HDAC8P2RX7SRC
SCHEMBL7895615 0.81 L3MBTL1 (0.39) HDAC8HPGD
SCHEMBL7599531 0.81 ALDH1A1 (0.44) P2RX7HPGD
SCHEMBL7893949 0.81 CD38 (0.41) CYP3A4CD38P2RX7CXCR2
SCHEMBL7894185 0.80 PLK1 (0.37) CYP3A4CD38HDAC8HDAC3HDAC1
SCHEMBL7895088 0.79 CD38 (0.40) CYP3A4CD38P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP claimed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP claimed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US claimed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO claimed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed