Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 5/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.40 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895070 | 0.86 | ABCC9 (0.55) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7895708 | 0.83 | PLK1 (0.42) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7895472 | 0.83 | CHEK2 (0.43) | CHEK1ROCK2CHEK2GSK3AGSK3B | |
| SCHEMBL8370799 | 0.81 | PLK1 (0.54) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL8370803 | 0.81 | PLK1 (0.54) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7886866 | 0.80 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7894022 | 0.80 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7886860 | 0.80 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PLK1 | |
| SCHEMBL7894223 | 0.80 | CHEK2 (0.41) | CHEK1ROCK2CHEK2GSK3AGSK3B | |
| SCHEMBL7895113 | 0.77 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11KCNJ8PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | claimed |
| US-5780505-A | ADMINISTERING AS SMOOTH MUSCLE RELAXANT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-07-14 | — | — | US | claimed |
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | disclosed |