Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PRKX | P51817 | 2/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.52 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370803 | 1.00 | PLK1 (0.54) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL7894993 | 0.81 | ABCC9 (0.47) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8372683 | 0.79 | PLK1 (0.67) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL7347226 | 0.79 | PLK1 (0.67) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8624137 | 0.78 | ABCC9 (0.41) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8369787 | 0.78 | PLK1 (0.64) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL9091165 | 0.74 | PLK1 (0.59) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8372678 | 0.74 | PLK1 (0.59) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8369788 | 0.74 | PLK1 (0.59) | PLK1CHEK1PLK4DAPK3ROCK2 | |
| SCHEMBL8664788 | 0.73 | ABCG2 (0.41) | PLK1CHEK1PLK4DAPK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796243-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PROD (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0796243-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-24 | — | — | EP | disclosed |
| US-5530025-A | SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-25 | — | — | US | disclosed |
| WO-1996015103-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |