Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 7/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10241140 | 0.86 | CACNA1I (0.51) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL759248 | 0.80 | STIM1 (0.66) | CACNA1GCACNA1ISMN1; SMN2LMNANPC1 | |
| SCHEMBL10280779 | 0.79 | TSHR (0.42) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL3439966 | 0.71 | CACNA1G (0.50) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL2113322 | 0.71 | MAPT (0.58) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL561363 | 0.69 | NPC1 (0.46) | SMN1; SMN2LMNANPC1RAB9AALDH1A1 | |
| SCHEMBL16118387 | 0.69 | KMT2A (0.67) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL3439967 | 0.69 | STIM1 (0.53) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL24335590 | 0.68 | SMN1; SMN2 (0.59) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA | |
| SCHEMBL18593147 | 0.67 | CACNA1I (0.72) | CACNA1GCACNA1ICACNA1HSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010122089-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |