Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10241140 | 0.79 | CACNA1I (0.51) | TSHRCACNA1GCACNA1ICACNA1HLMNA | |
| SCHEMBL7895013 | 0.79 | CACNA1G (0.49) | CACNA1GCACNA1ICACNA1HLMNASMN1; SMN2 | |
| SCHEMBL759248 | 0.73 | STIM1 (0.66) | TSHRCACNA1GCACNA1ILMNASMN1; SMN2 | |
| SCHEMBL27765530 | 0.72 | EPHX2 (0.43) | TSHRCYP2D6CACNA1GCACNA1ICACNA1H | |
| SCHEMBL28304418 | 0.68 | KDM4E (0.35) | CYP2D6CACNA1GCACNA1ICACNA1HALDH1A1 | |
| SCHEMBL4990040 | 0.66 | TSHR (0.65) | TSHRCYP2D6HIF1AMPOCA12 | |
| SCHEMBL561363 | 0.65 | NPC1 (0.46) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10917974 | 0.65 | BRD4 (0.56) | TSHRCYP2D6HIF1AMPOCA12 | |
| SCHEMBL2113322 | 0.64 | MAPT (0.58) | TSHRCACNA1GCACNA1ICACNA1HLMNA | |
| SCHEMBL3439966 | 0.64 | CACNA1G (0.50) | TSHRCACNA1GCACNA1ICACNA1HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399436-B2 | N-pyrazolyl carboxamides as CRAC channel inhibitors | GLAXO GROUP LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
| US-20100273744-A1 | COMPOUNDS | GORE PAUL MARTIN | 2010-10-28 | — | — | US | disclosed |
| US-20100273744-A1 | COMPOUNDS | GORE PAUL MARTIN | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | ORAI1, TRPV1, CACNA1E | TSHR 3152/4885CYP2D6 3303/4885HIF1A 1334/4885 |
| US-20100273744-A1 | COMPOUNDS | LTC4S, HRH4, HRH2 | TSHR 4136/4885CYP2D6 164/4885HIF1A 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.