Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.62 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549977 | 0.86 | CA2 (0.48) | HRH1HTR1ASLC6A2SLC6A3CHRM3 | |
| SCHEMBL9988552 | 0.82 | CA1 (0.45) | HRH1HTR1ASLC6A2SLC6A3CHRM3 | |
| SCHEMBL873580 | 0.82 | CA1 (0.45) | HRH1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1833804 | 0.81 | MCHR1 (0.45) | HRH1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1836440 | 0.81 | MCHR1 (0.45) | HRH1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1834837 | 0.81 | MCHR1 (0.45) | HRH1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL234010 | 0.78 | SLC6A2 (0.81) | HRH1HTR1ASLC6A2SLC6A3CHRM3 | |
| SCHEMBL82594 | 0.78 | HRH1 (0.62) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL82955 | 0.78 | HRH1 (0.62) | HRH1HTR1ASLC6A2SLC6A3KCNH2 | |
| SCHEMBL1229562 | 0.78 | HRH1 (0.62) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |