Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873580 | 0.96 | CA1 (0.45) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL1836440 | 0.94 | MCHR1 (0.45) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL1833804 | 0.94 | MCHR1 (0.45) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL1834837 | 0.94 | MCHR1 (0.45) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL2549977 | 0.91 | CA2 (0.48) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL7895152 | 0.82 | HRH1 (0.62) | HRH1SLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL19837798 | 0.82 | KAT2B (0.56) | CA1CA2TP53TSHRJAK2 | |
| SCHEMBL1053225 | 0.80 | MCHR1 (0.47) | CA1CA2TP53LMNAMAPT | |
| SCHEMBL5344402 | 0.80 | MCHR1 (0.49) | HRH1SLC6A4SLC6A2SLC6A3MCHR1 | |
| SCHEMBL1836727 | 0.79 | MCHR1 (0.43) | TP53LMNAMAPTSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |