Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031086 | 0.82 | HRH1 (0.54) | HRH1CYP3A4CYP2D6TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6030477 | 0.81 | HRH1 (0.55) | HRH1CYP3A4CYP2D6TSHRSMN1; SMN2 | |
| SCHEMBL6030048 | 0.81 | SIGMAR1 (0.43) | HRH1SIGMAR1 | |
| SCHEMBL6030987 | 0.80 | SIGMAR1 (0.53) | OPRD1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL6031884 | 0.79 | SIGMAR1 (0.37) | HRH1CYP3A4CYP2D6TSHRALDH1A1 | |
| SCHEMBL6031686 | 0.78 | SIGMAR1 (0.55) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6100154 | 0.77 | SIGMAR1 (0.38) | HRH1SIGMAR1 | |
| Iodide SCHEMBL6031820 | 0.75 | SIGMAR1 (0.56) | OPRD1OPRK1HRH1SIGMAR1 | |
| Isopropyl Alcohol SCHEMBL6101083 | 0.75 | SIGMAR1 (0.39) | HRH1SIGMAR1 | |
| SCHEMBL6030965 | 0.75 | OPRD1 (0.55) | OPRD1OPRK1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144411-A1 | ANTIHISTAMINIC SPIRO COMPOUNDS | Janssen Pharmaceutica N.V. (BE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037470-A1 | ANTIHISTAMINIC SPIRO COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-06-29 | — | — | WO | disclosed |