Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | NEK4 | P51957 | 2/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886894 | 0.91 | LOXL2 (0.49) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7894067 | 0.84 | LOXL2 (0.59) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7887143 | 0.81 | LOXL2 (0.47) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7894087 | 0.80 | LOXL2 (0.50) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7887274 | 0.80 | LOXL2 (0.50) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7886881 | 0.80 | LOXL2 (0.50) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7886885 | 0.80 | LOXL2 (0.46) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7886886 | 0.80 | LOXL2 (0.46) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7895099 | 0.80 | LOXL2 (0.46) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 | |
| SCHEMBL7895618 | 0.78 | LOXL2 (0.47) | LOXL2CYP2A6CYP19A1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | claimed |
| EP-0934257-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | claimed |
| WO-1998002413-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-22 | — | — | WO | claimed |
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-0934257-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1998002413-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |