Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894087 | 0.88 | LOXL2 (0.50) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7886860 | 0.86 | ABCC9 (0.58) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7894022 | 0.86 | ABCC9 (0.58) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7886866 | 0.86 | ABCC9 (0.58) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7886885 | 0.84 | LOXL2 (0.46) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7886886 | 0.84 | LOXL2 (0.46) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7887143 | 0.83 | LOXL2 (0.47) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7887274 | 0.82 | LOXL2 (0.50) | LOXL2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7894067 | 0.80 | LOXL2 (0.59) | LOXL2CYP19A1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL8373578 | 0.79 | ABCC9 (0.47) | ABCC9ABCC8KCNJ11KCNJ8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | claimed |
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | claimed |
| EP-1151990-A1 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5846999-A | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |