Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893075 | 0.83 | EPHX2 (0.67) | EPHX2EPHX1 | |
| SCHEMBL5361247 | 0.82 | EPHX2 (0.50) | EPHX2EPHX1DPP4DPP8CA1 | |
| SCHEMBL18559935 | 0.82 | EPHX2 (0.50) | EPHX2EPHX1DPP4DPP8CA1 | |
| SCHEMBL23573522 | 0.82 | EPHX1 (0.42) | EPHX2EPHX1ALDH1A1KDM1AMAOA | |
| SCHEMBL14366334 | 0.80 | EPHX2 (0.49) | EPHX2EPHX1DPP4DPP8CA1 | |
| SCHEMBL23011884 | 0.80 | EPHX2 (0.41) | EPHX2EPHX1ALDH1A1KDM1AMAOA | |
| SCHEMBL12846737 | 0.79 | EPHX2 (0.49) | EPHX2EPHX1 | |
| SCHEMBL12545762 | 0.79 | EPHX2 (0.45) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL13654292 | 0.79 | ATM (0.44) | EPHX2EPHX1DPP4DPP8CA1 | |
| SCHEMBL12812332 | 0.79 | KDM1A (0.42) | EPHX2EPHX1ALDH1A1ATMKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |
| WO-2010065717-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2010-06-10 | — | — | WO | disclosed |
| WO-2005090354-A1 | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |