Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL7896592 | 0.98 | NCF1 (0.46) | NCF1GAAKEAP1NR1H2NR1H3 | |
| Ammonia Solution, Strong SCHEMBL7895913 | 0.95 | NR1H2 (0.50) | NCF1GAAKEAP1NR1H2NR1H3 | |
| Ammonia Solution, Strong SCHEMBL7897572 | 0.94 | NR1H2 (0.52) | NCF1GAAKEAP1NR1H2NR1H3 | |
| SCHEMBL23118277 | 0.93 | NR1H2 (0.51) | NCF1GAAKEAP1NR1H2NR1H3 | |
| SCHEMBL11500344 | 0.93 | NR1H2 (0.51) | NCF1GAAKEAP1NR1H2NR1H3 | |
| SCHEMBL28169250 | 0.92 | NR1H2 (0.54) | NCF1GAAKEAP1NR1H2NR1H3 | |
| SCHEMBL21593838 | 0.86 | NCF1 (0.50) | NCF1GAAKEAP1MAPK1DRD2 | |
| Ammonia Solution, Strong SCHEMBL7896018 | 0.84 | KEAP1 (0.52) | NCF1GAAKEAP1MAPK1DRD2 | |
| Ammonia Solution, Strong SCHEMBL7898885 | 0.83 | MEN1 (0.51) | GAANR1H2NR1H3LMNADRD2 | |
| SCHEMBL6514775 | 0.82 | KEAP1 (0.53) | NCF1GAAKEAP1MAPK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |
| US-4735959-A | HYPOGLYCEMIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1988-04-05 | — | — | US | disclosed |