Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896858 | 0.81 | TOP2A (0.71) | TOP1TOP2AMEN1KMT2A | |
| SCHEMBL7912659 | 0.69 | TOP2A (0.71) | TOP1TOP2AMEN1KMT2A | |
| SCHEMBL12281495 | 0.69 | L3MBTL1 (0.49) | TOP1MEN1KMT2A | |
| SCHEMBL18326525 | 0.66 | KDM4E (0.39) | TOP1TOP2AMEN1KMT2ASIRT1 | |
| SCHEMBL17933496 | 0.62 | MAPK1 (0.46) | AHR | |
| SCHEMBL3692372 | 0.60 | HTR2A (0.60) | MEN1KMT2A | |
| SCHEMBL13865458 | 0.60 | HTR2A (0.60) | MEN1KMT2A | |
| SCHEMBL3261837 | 0.59 | STK17B (0.50) | MEN1KMT2A | |
| SCHEMBL1989430 | 0.59 | CYP2A6 (0.57) | — | |
| SCHEMBL835538 | 0.58 | ALOX15 (0.68) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075280-A2 | COUMARIN-BASED COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-07-01 | — | — | WO | disclosed |