Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.60 |
| ▸ | RARG | P13631 | 12/20 | 0.60 |
| ▸ | RARA | P10276 | 11/20 | 0.60 |
| ▸ | RXRA | P19793 | 11/20 | 0.60 |
| ▸ | RXRB | P28702 | 7/20 | 0.60 |
| ▸ | RXRG | P48443 | 5/20 | 0.60 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7889455 | 0.86 | RXRA (0.61) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756626 | 0.84 | CYP26A1 (0.65) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756622 | 0.84 | CYP26A1 (0.65) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756615 | 0.81 | RXRA (0.77) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756675 | 0.81 | RARB (0.81) | RARBRARGRARARXRARXRB | |
| SCHEMBL7759779 | 0.78 | RARA (0.51) | RARBRARGRARARXRARXRB | |
| SCHEMBL7761551 | 0.78 | RARA (0.51) | RARBRARGRARARXRARXRB | |
| SCHEMBL7896511 | 0.77 | RXRA (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL7897272 | 0.77 | RXRA (0.56) | RARBRARGRARARXRARXRB | |
| SCHEMBL8124463 | 0.77 | RARA (0.62) | RARBRARGRARACYP26A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |