Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897506 | 0.93 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9895879 | 0.93 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL7896386 | 0.91 | HDAC3 (0.39) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9895162 | 0.91 | HDAC3 (0.39) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL10072240 | 0.89 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL7896028 | 0.84 | HDAC3 (0.51) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL9946573 | 0.81 | HDAC1 (0.38) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL10072096 | 0.81 | MAP3K7 (0.34) | SMN1; SMN2NPC1RAB9AHDAC1HDAC4 | |
| SCHEMBL10072275 | 0.81 | MAP3K7 (0.33) | SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL7899126 | 0.81 | MAP3K7 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097586-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-09-02 | — | — | WO | disclosed |