Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.64 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768421 | 0.93 | LMNA (0.66) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7896558 | 0.93 | ABCC8 (0.61) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7896571 | 0.93 | ABCC8 (0.67) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7888559 | 0.92 | ABCC8 (0.60) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7888617 | 0.90 | LMNA (0.65) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7900185 | 0.89 | ABCC8 (0.64) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL10765048 | 0.89 | ABCC8 (0.60) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7897483 | 0.89 | ABCC8 (0.60) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7898583 | 0.88 | LMNA (0.63) | ABCC8LMNASLC22A1ABCC3ABCC4 | |
| SCHEMBL7896633 | 0.88 | ABCC8 (0.58) | ABCC8LMNASLC22A1ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |