Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897668 | 0.80 | FNTA (0.44) | KCNA3BCL2L1MAOBMAOAPPARG | |
| SCHEMBL7910059 | 0.75 | FNTA (0.60) | KMT2AFNTAFNTB | |
| SCHEMBL7910060 | 0.75 | FNTA (0.60) | KMT2AFNTAFNTB | |
| SCHEMBL7907270 | 0.75 | FNTA (0.41) | ALDH1A1MEN1KMT2AFNTAFNTB | |
| SCHEMBL4460274 | 0.74 | MAOB (0.57) | ALDH1A1MAOBMAOAPPARGMEN1 | |
| SCHEMBL11593773 | 0.72 | P2RY14 (0.60) | ALDH1A1MAOBMAOAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9222328 | 0.71 | P2RY14 (0.59) | ALDH1A1MAOBMAOAMEN1KMT2A | |
| SCHEMBL8973061 | 0.68 | RAB9A (0.61) | ALDH1A1MAOBPPARG | |
| SCHEMBL6777951 | 0.68 | FNTA (0.60) | FNTAFNTB | |
| SCHEMBL6777949 | 0.68 | FNTA (0.60) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |