Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898016 | 1.00 | GRM2 (0.48) | GRM2ACACBNPC1RAB9AL3MBTL1 | |
| SCHEMBL27535346 | 0.89 | TP53 (0.43) | GRM2ACACBNPC1RAB9AL3MBTL1 | |
| SCHEMBL7898037 | 0.82 | ACACB (0.45) | ACACBNPC1RAB9AKDM4EMAPT | |
| SCHEMBL7898038 | 0.82 | ACACB (0.45) | ACACBNPC1RAB9AKDM4EMAPT | |
| SCHEMBL7898035 | 0.82 | ACACB (0.45) | ACACBNPC1RAB9AKDM4EMAPT | |
| SCHEMBL735870 | 0.80 | MAPT (0.52) | NPC1RAB9AL3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL27473865 | 0.77 | HRH3 (0.54) | ACACBNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13279833 | 0.76 | GSTP1 (0.52) | NPC1RAB9AL3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL22411529 | 0.76 | RAB9A (0.53) | ACACBNPC1RAB9AKDM4EMAPT | |
| SCHEMBL10437652 | 0.76 | HRH3 (0.58) | NPC1RAB9AL3MBTL1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |