Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089244 | 0.87 | HRH3 (0.74) | HRH3CYP2D6HRH1GRIN1GRIN2B | |
| SCHEMBL735870 | 0.86 | MAPT (0.52) | HRH3RAB9ANPC1MAPTLMNA | |
| SCHEMBL16046663 | 0.85 | LTA4H (0.62) | HRH3RAB9ANPC1TP53MAPT | |
| SCHEMBL13202898 | 0.84 | RAB9A (0.67) | HRH3PRMT5RAB9ANPC1TP53 | |
| SCHEMBL9047395 | 0.84 | LTA4H (0.60) | HRH3RAB9ANPC1LMNALTA4H | |
| SCHEMBL738629 | 0.84 | MAOB (0.54) | HRH3RAB9ANPC1TP53MAPT | |
| SCHEMBL2342568 | 0.83 | LMNA (0.51) | HRH3RAB9ANPC1TP53MAPT | |
| SCHEMBL13279833 | 0.82 | GSTP1 (0.52) | RAB9ANPC1MAPTLMNALTA4H | |
| SCHEMBL7891469 | 0.82 | MAPT (0.49) | HRH3RAB9ANPC1MAPTLMNA | |
| SCHEMBL335477 | 0.81 | LTA4H (0.64) | PRMT5MAPTLMNALTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |