Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260027 | 1.00 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL3717970 | 1.00 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL17864289 | 1.00 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL3717972 | 1.00 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL1645757 | 1.00 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL13598557 | 0.96 | KDM1A (0.63) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| Pivalamide SCHEMBL8323779 | 0.84 | KDM1A (0.46) | KDM1ASLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4607109 | 0.82 | KDM1A (0.43) | KDM1ASLC6A4SLC6A3KCNH2MAOB | |
| SCHEMBL4608247 | 0.81 | KDM1A (0.39) | KDM1ASLC6A2HTR2CSLC6A3KCNH2 | |
| SCHEMBL4606753 | 0.81 | KDM1A (0.42) | KDM1AHTR2ANOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |