Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17864289 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL3717972 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL4260027 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL1645757 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL7898071 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL3717970 | 0.84 | KDM1A (0.63) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL13598557 | 0.81 | KDM1A (0.63) | KDM1ANR3C2SLC9A1SLC6A3SLC6A2 | |
| SCHEMBL4608144 | 0.73 | SLC9A1 (0.50) | KDM1ANR3C2SLC9A1HRH3SLC6A3 | |
| SCHEMBL1644777 | 0.73 | SLC6A2 (0.48) | KDM1ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27992795 | 0.70 | RPS6KB1 (0.41) | KDM1AHRH3SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858444-A4 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0858444-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014671-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-04-24 | — | — | WO | disclosed |