Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17573078 | 0.68 | HPGD (0.69) | HPGDNPSR1TSHRMAPTNPC1 | |
| SCHEMBL9512976 | 0.67 | TSHR (0.70) | HPGDCYP2C19NPSR1TSHRMAPT | |
| SCHEMBL12955837 | 0.66 | HPGD (0.56) | HPGDNPSR1TSHRMAPTNPC1 | |
| SCHEMBL10877860 | 0.63 | HPGD (0.53) | HPGDNPSR1MAPTNPC1RAB9A | |
| SCHEMBL11735496 | 0.62 | CYP2C19 (0.81) | HPGDCYP2C19TSHRMAPTKMT2A | |
| SCHEMBL20817036 | 0.62 | HPGD (0.48) | HPGDNPSR1MAPTNPC1RAB9A | |
| SCHEMBL14549384 | 0.62 | NPSR1 (0.62) | HPGDNPSR1CSF1RKDRMAPT | |
| SCHEMBL13061699 | 0.62 | HPGD (0.53) | HPGDNPSR1TSHRMAPTNPC1 | |
| SCHEMBL27438029 | 0.62 | CTSV (0.56) | HPGDMAPTRAB9AMEN1KMT2A | |
| SCHEMBL7343008 | 0.62 | APP (0.51) | CYP2C19NPSR1TSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | disclosed |