Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FURIN | P09958 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.37 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | S100B | P04271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10341873 | 0.93 | CYP3A4 (0.52) | TSHRCYP3A4L3MBTL1FURINGAA | |
| SCHEMBL10703892 | 0.91 | TSHR (0.50) | TSHRCYP3A4L3MBTL1FURINGAA | |
| SCHEMBL7602206 | 0.91 | TSHR (0.50) | TSHRCYP3A4L3MBTL1FURINGAA | |
| SCHEMBL1493053 | 0.89 | CYP3A4 (0.52) | TSHRCYP3A4L3MBTL1FURINGAA | |
| SCHEMBL10341829 | 0.87 | CYP3A4 (0.54) | TSHRCYP3A4L3MBTL1FURINPRSS1 | |
| SCHEMBL414168 | 0.84 | CYP1A2 (0.50) | TSHRCYP3A4GAAPRSS1TP53 | |
| SCHEMBL3707532 | 0.83 | NR5A1 (0.54) | TSHRGAATP53 | |
| SCHEMBL1020538 | 0.83 | NR5A1 (0.54) | TSHRGAATP53 | |
| SCHEMBL7777016 | 0.83 | NR5A1 (0.54) | TSHRGAATP53 | |
| SCHEMBL11848774 | 0.83 | NR5A1 (0.54) | TSHRGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999064041-A9 | MULTIBINDING AGENTS THAT MODULATE NMDA RECEPTORS | ADVANCED MEDICINE INC (US) | 2001-05-31 | — | — | WO | disclosed |
| EP-1100519-A1 | MULTIBINDING AGENTS THAT MODULATE NMDA RECEPTORS | Advanced Medicine, Inc. (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-1999064041-A1 | MULTIBINDING AGENTS THAT MODULATE NMDA RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |