Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.46 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.46 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.46 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901626 | 1.00 | LMNA (0.58) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7894149 | 0.92 | LMNA (0.50) | LMNAPOLBKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8894553 | 0.88 | NPC1 (0.50) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| Water SCHEMBL9411708 | 0.87 | NPC1 (0.49) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7901630 | 0.86 | LMNA (0.50) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8894458 | 0.86 | NPC1 (0.48) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7901474 | 0.86 | NPC1 (0.50) | LMNAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7894167 | 0.86 | LMNA (0.58) | LMNAPOLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7901368 | 0.83 | LMNA (0.50) | LMNAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7894112 | 0.83 | NPC1 (0.52) | LMNAPOLBKDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37094-E1 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 2001-03-13 | — | — | US | claimed |
| EP-0432040-B2 | Heterocyclic derivatives of acylaminothiazole, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-12-17 | — | — | EP | claimed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | claimed |
| JP-3279374-A | — | — | None | — | — | JP | disclosed |
| US-RE37094-E1 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 2001-03-13 | — | — | US | disclosed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | disclosed |
| JP-H03279374-A | HETEROCYCLIC SUBSTITUTED ACYLAMINOTHIAZOLE | SANOFI SA | 1991-12-10 | — | — | JP | disclosed |