Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.47 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.47 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.47 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATP4A | P20648 | 1/20 | 0.46 |
| ▸ | ATP4B | P51164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894149 | 0.89 | LMNA (0.50) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL7818402 | 0.87 | LMNA (0.57) | NPC1RAB9ALMNASMN1; SMN2TYR | |
| SCHEMBL7894249 | 0.86 | MAPT (0.57) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL7901626 | 0.86 | LMNA (0.58) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL7899704 | 0.86 | LMNA (0.58) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL7894167 | 0.84 | LMNA (0.58) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL8895004 | 0.82 | KMT2A (0.48) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL8894553 | 0.82 | NPC1 (0.50) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| Water SCHEMBL9411708 | 0.81 | NPC1 (0.49) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8896967 | 0.81 | NPC1 (0.47) | NPC1RAB9ALMNASMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37094-E1 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 2001-03-13 | — | — | US | claimed |
| EP-0432040-B2 | Heterocyclic derivatives of acylaminothiazole, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-12-17 | — | — | EP | claimed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | claimed |
| US-RE37094-E1 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 2001-03-13 | — | — | US | disclosed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | disclosed |