Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844873 | 0.80 | TAAR1 (0.42) | NPC1RAB9ASMN1; SMN2IDO1MEN1 | |
| SCHEMBL11410252 | 0.68 | IDO1 (0.58) | MAPK1TSHRTDP1IDO1ALDH1A1 | |
| SCHEMBL1149394 | 0.68 | IDO1 (0.58) | MAPK1TSHRTDP1IDO1ALDH1A1 | |
| SCHEMBL21994328 | 0.63 | IDO1 (0.46) | TDP1IDO1ALDH1A1HTTLMNA | |
| SCHEMBL9403954 | 0.63 | SLC6A2 (0.47) | TSHRTDP1IDO1LMNAALOX12 | |
| SCHEMBL25449537 | 0.62 | LTA4H (0.52) | NPC1RAB9AMAPK1TSHRTDP1 | |
| SCHEMBL1741096 | 0.62 | LTA4H (0.52) | NPC1RAB9AMAPK1TSHRTDP1 | |
| SCHEMBL275839 | 0.60 | CALM1 (0.67) | NPC1RAB9ASMN1; SMN2TSHRTDP1 | |
| SCHEMBL2140291 | 0.60 | CALM1 (0.67) | NPC1RAB9ASMN1; SMN2TSHRTDP1 | |
| SCHEMBL6548000 | 0.60 | IDO1 (0.48) | TDP1IDO1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001002355-A2 | INDOLE SYNTHESIS | AXYS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | claimed |
| WO-2001002355-A2 | INDOLE SYNTHESIS | AXYS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |